4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

Reexamination Certificate

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Details

C514S569000, C514S571000, C558S410000, C562S426000, C562S470000

Reexamination Certificate

active

07598292

ABSTRACT:
The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.

REFERENCES:
patent: 7301050 (2007-11-01), Kuo et al.
patent: 2005/0124698 (2005-06-01), Kuo et al.
patent: WO 03/011807 (2003-02-01), None
patent: WO 03/074495 (2003-09-01), None
Oliver, B. et al., “Differential Expression of Peroxisome Proliferator-Activated Receptors (PPARs): Tissue Distribution of PPAR-α, -β, and -γ in the Adult Rat*.”Endocrinology, 1996, 354-366, 137, No. 1.
Auboeuf, D. et al., “Tissue Distribution and Quantification of the Expression of mRNAs of Peroxisome Proliferator-Activated Receptors and Liver X Receptor-α in Humans No Alteration in Adipose Tissue of Obese and NIDDM Patients.”Diabetes, 1997, 1319-1327, vol. 46.
Boden, G. “Free Fatty Acids, Insulin Resistance, and Type 2 Diabetes Mellitus.”PAAP, 1999, 241-248, vol. 111, No. 3.
Lawn, R. M. et al., “The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway.”J. Clin. Invest., 1999, R25-R31, vol. 104, No. 8.
Leibowitz, M. D. et al., “Activation of PPARδ alters lipid metabolism in db/db mice/”FEBS, 2000, 336-336, vol. 473.
Oliver, W. R. et al., “A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport.”PNAS, 2001, 5306-5311, vol. 98, No. 9.
Shi, Y. et al., “The peroxisome proliferator-activated receptor δ, an integrator of transcriptional repression and nuclear receptor signaling.”PNAS, 2002, 2613-2618, vol. 99, No. 5.
Berge et al., “Pharmaceutical Salts.”, J. Pharm.Sci., 1977, vol. 66(1), pp. 1-19.
Sznaidman et al., “Novel Selective Small Molecule Agonists for Peroxisome Proliferator-Activated Receptor δ (PPARδ)-Synthesis and Biological Activity.”, Bioorganic & Medicinal Chemistry Letters, 2003, vol. 13. pp. 1517-1521.

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