4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs

Details 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs

2007-10-15

2009-12-22

Keys, Rosalynd (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

C514S571000, C562S426000, C562S465000, C562S471000, C562S472000

Reexamination Certificate

active

07635718

ABSTRACT:
The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.

REFERENCES:
patent: 4820867 (1989-04-01), Bellanger et al.
patent: 5726165 (1998-03-01), Beeley et al.
patent: 7301050 (2007-11-01), Kuo et al.
patent: 2005/0107469 (2005-05-01), Kuo et al.
patent: 2006/0058382 (2006-03-01), Kuo et al.
patent: 2006/0058393 (2006-03-01), DeAngelis et al.
patent: 2006/0257987 (2006-11-01), Gonzalez Valcarcel
patent: 2007/0060649 (2007-03-01), Abdel-Magid et al.
patent: 0 056 172 (1982-07-01), None
patent: WO 03/011807 (2003-02-01), None
patent: WO 03/074495 (2003-09-01), None
patent: WO 2005/030694 (2005-04-01), None
PCT International Search Report dated May 25, 2005 for PCT/US2004/030375 which relates to U.S. Appl. No. 10/942,478.
Auboeuf et al., “Tissue Distribution and Quantification of the Expression of mRNAs of Peroxisome Proliferator-Activated Receptors and Liver X Receptor-α in Humans.”, Diabetes, 1997, vol. 46, pp. 1319- 1327. Aug. 1997.
Berge et al., “Pharmaceutical Salts.”, J. Pharm.Sci., 1977, vol. 66(1), pp. 1-19. Jan. 1977.
Boden, G., “Free Fatty Acids, Insulin Resistance, and Type 2 Diabetes Mellitus”, Proceedings of the Association of American Physicians, 1999, vol. 111(3), pp. 241-248. May/Jun. 1999.
Braissant et al., “Differential Expression of Peroxisome Proliferator-Activated Receptors (PPARs): Tissue Distribution of PPAR-α, -β, and -γ in the Adult Rat*. ”, Endrocrinology, 1996, vol. 137(1), pp. 354-366.
Lawn et al., “The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway.”, J. Clin. Investigation, 1999, vol. 104(8), pp. R25-R31.
Shi et al., “The peroxisome proliferator-activated receptor ,an integrator of transcriptional opressioo and nuclear receptor signaling.”, Proc Natl. Acad. Sci., 2002, vol. 99(5), pp. 2613-2618, USA. Mar. 2002.
Sznaidman et al., “Novel Selective Small Molecule Agonists for Peroxisome Proliferator-Activated Receptor δ (PPARδ)-Synthesis and Biological Activity.”, Bioorganic & Medicinal Chemistry Letters, 2003, vol. 13. pp. 1517-1521.

Affiliated with

Also associated with

Rating

4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4067432