4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

Reexamination Certificate

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Details

C562S496000, C514S521000, C514S559000, C514S561000, C514S599000, C558S410000

Reexamination Certificate

active

11226645

ABSTRACT:
The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.

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patent: WO 02/100813 (2002-12-01), None
Oliver, B. et al., “Differential Expression of Peroxisome Proliferator-Activated Receptors (PPARs): Tissue Distribution of PPAR-α, -β, and -γin the Adult Rat.”Endocrinology, 1996, 354-366, 137, No. 1.
Boden, G. “Free Fatty Acids, Insulin Resistance, and Type 2 Diabetes Mellitus.”PAAP, 1999, 241-248, vol. 111, No. 3.
Leibowitz, M. D. et al., “Activation of PPARδ alters lipid metabolism in db/db mice.”FEBS, 2000, 333-336, vol. 473.
PCT International Search Report, dated Jun. 3, 2006 for PCT Appln. No. PCT/US2005/032938 which relates to U.S. Appl. No. 11/226,645, filed Sep. 14, 2005.
Written Opinion on the International Searching Authority for PCT Application No. PCT/US/2005/032938.

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