4-oxoquinoline compound and use thereof as pharmaceutical agent

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C546S156000

Reexamination Certificate

active

10492833

ABSTRACT:
An anti-HIV agent containing, as an active ingredient, a 4-oxoquinoline compound represented by the following formula [I]wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof. The compound of the present invention has HIV integrase inhibitory action and is useful as an anti-HIV agent for the prophylaxis or therapy of AIDS. Moreover, by a combined use with other anti-HIV agents such as protease inhibitors, reverse transcriptase inhibitors and the like, the compound can become a more effective anti-HIV agent. Since the compound has high inhibitory activity specific for integrases, it can provide a safe pharmaceutical agent with a fewer side effects for human.

REFERENCES:
patent: 3472859 (1969-10-01), Lesher
patent: 5519016 (1996-05-01), Kimura et al.
patent: 5688791 (1997-11-01), Kimura et al.
patent: 5985894 (1999-11-01), Clemence et al.
patent: 6034086 (2000-03-01), Kimura et al.
patent: 6248736 (2001-06-01), Turner et al.
patent: 6248738 (2001-06-01), Dickinson et al.
patent: 6559145 (2003-05-01), Ciske et al.
patent: 2004/0127708 (2004-07-01), Fuji et al.
patent: 2004/0198716 (2004-10-01), Arad et al.
patent: 498721 (1992-08-01), None
patent: 1140851 (2001-10-01), None
patent: 1375486 (2004-01-01), None
patent: A 48 26 772 (1973-04-01), None
patent: A 43 60 872 (1992-12-01), None
patent: 6-116241 (1994-04-01), None
patent: 6-199635 (1994-07-01), None
patent: 6-271568 (1994-09-01), None
patent: 8-183776 (1996-07-01), None
patent: 10-316570 (1998-12-01), None
patent: 2002-293745 (2002-10-01), None
patent: A 2002-534416 (2002-10-01), None
patent: A 2002-534417 (2002-10-01), None
patent: WO 97/38999 (1997-10-01), None
patent: WO98/45269 (1998-10-01), None
patent: WO 00/001714 (2000-01-01), None
patent: WO 00/40561 (2000-07-01), None
patent: WO 00/40563 (2000-07-01), None
patent: WO 01/98275 (2001-12-01), None
patent: WO 02/004444 (2002-01-01), None
patent: WO 02/36734 (2002-05-01), None
patent: WO 02/55079 (2002-07-01), None
patent: WO 02/070486 (2002-09-01), None
patent: WO 02/076939 (2002-10-01), None
Guidelines for the Use of Antiretroviral Agents in HIV-infected Adults and Adolescent, pp. i-iii and 1-111, (Aug. 13, 2001).
Hirao, I. et al.,Studies on the Synthesis of Quinoline Compounds, I. Memoirs Kyushu Inst. Tech. (Eng.), 14:13-16 (1984).
Hirao, I. et al.,Antibacterial Activities of Oxodihydroquinoline Carboxylic Acid Derivatives, Memoirs Department of Engineering, 14:21-32 (1990).
Vincent, K.A., et al.,Characterization of Human Immunodeficiency Virus Type I Integrase Expressed in Eschericia coli and Analysis of Variants with Amino-Terminal Mutations, J. Virol. 67: 425-437 (1993).
Ab dul-Ahad, Europ Jor Med Chem, 17(4) pp. 301-306, 1982.
Yoshimoto, J Med Chem, 19(1.) pp. 71-98, 1976.
Baker, J Med Chem, 15(3) pp. 235-237, 1972.
Walton, Antimicrobial Agents & Chemotherapy 32(7) pp. 1086-1089, 1988.
Stefaurich, Farmaro, Edizioie Scientifica 42(1) pp. 3-16, 1987.
Search Report from Austrian Patent Office dated Apr. 3, 2006.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

4-oxoquinoline compound and use thereof as pharmaceutical agent does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4-oxoquinoline compound and use thereof as pharmaceutical agent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-oxoquinoline compound and use thereof as pharmaceutical agent will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3857915

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.