4-Oxo-PGI.sub.2 compounds, their use in inhibition of thrombii a

Details 4-Oxo-PGI.sub.2 compounds, their use in inhibition of thrombii a 4-Oxo-PGI.sub.2 compounds, their use in inhibition of thrombii a

1982-04-13

1984-03-20

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Bacterium or component thereof or substance produced by said...

549465, 549214, A61K 31557, C07D307935

Patent

active

044381328

ABSTRACT:
The invention relates to a process for the preparation of novel 4-oxo-PGI.sub.2 derivatives of formula I ##STR1## where (a) compounds of formula III ##STR2## are oxidized, then the obtained 5-substituted-4-oxo-PGI.sub.1 derivatives of general formula II ##STR3## are eliminated by the splitting off of the W-H-molecule, or (b) the compounds of formula IV ##STR4## are reacted in a solvent in the presence of a catalyst with compounds of general formula V ##STR5## then the obtained compounds of formula I are transformed if desired by saponification, hydrolysis, salt formation, insertion of a protection group to another compound which belongs to the compounds of formula I, too.
The pharmaceutical products of the invention can be used for the treatment of circulatory diseases, they inhibit the aggregation of blood plaques, dilate the bronchi and inhibit the secretion of gastric acid.

REFERENCES:
patent: 4126744 (1968-11-01), Ayer

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