4-Oxo-PGI.sub.1 compounds

Details 4-Oxo-PGI.sub.1 compounds 4-Oxo-PGI.sub.1 compounds

1977-12-05

1978-11-21

Jiles, Henry R.

Harness for working animal

542429, 544153, 544376, 26032636, 26034622, 26034673, 546196, 546194, 546256, 546269, C07D30793

Patent

active

041267443

ABSTRACT:
This invention relates to certain structural and pharmacological analogs of 5,6-dihydro-prostacyclin (PGI.sub.1) wherein the C-4 position is substituted by oxo. These novel 4-oxo-prostacyclin-type compounds are useful for the same pharmacological purposes as prostacyclin, particularly being smooth muscle stimulators and platelet aggregation inhibitors.

REFERENCES:
pace-Asuak et al., Biochemistry, vol. 10, (20), 1971, pp. 3657-3664.

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