4-oxo-benzopyran carboxylic acids

Details 4-oxo-benzopyran carboxylic acids 4-oxo-benzopyran carboxylic acids

1984-03-19

1986-09-02

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549400, 549401, 549403, 549289, 549287, 549 79, 549 60, 549 51, 549 23, 548482, 548525, 546156, 546157, 546269, 546342, 544359, 544380, 544383, C07D31122, C07D31124

Patent

active

046097449

ABSTRACT:
Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are leukotriene antagonists. These compounds inhibit SRS-A and leukotriene synthesis and are antagonists of SRS-A and are thus useful in the treatment of asthma, allergic disorders, inflammation, skin diseases and certain cardiovascular disorders.

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patent: 4296129 (1981-10-01), Kadis
patent: 4299969 (1981-11-01), Huffman
Piper et al., Ann Rpts. Med. Chem., 15 69 (1980).
Borgeat and Sirois, J. Med. Chem., 24 121 (1981).
Samuelsson, Science, 220 568 (1983).
Bailey et al., Ann Rpts. Med. Chem., 17 203 (1982).
Chemical Abstracts, vol. 86, No. 13, Columbus, Ohio, U.S.A., R. A. Appleton et al., p. 14, abstract No. 86:83500n, J. Med. Chem., 1977, 20(3), pp. 371-379.
Chemical Abstracts, vol. 97, No. 3, Columbus, Ohio, U.S.A., P. Sheard et al.: p. 44, abstract-No. 97:16807g & Adv. Prostaglandin, Thromboxane, Leukotriene Res., 1982, 9 (Leukotrienes, etc.), pp. 229-235.

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