4-Oxo-2-carboxyl quinoline derivatives used as antiallergic comp

Details 4-Oxo-2-carboxyl quinoline derivatives used as antiallergic comp 4-Oxo-2-carboxyl quinoline derivatives used as antiallergic comp

1975-11-26

1979-05-29

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546108, 546110, 562455, 562433, 562456, 562457, 560 44, A61K 3147, C07D21548

Patent

active

041567269

ABSTRACT:
There are described compounds of formula I, ##STR1## in which R.sub.5 to R.sub.8 may be a variety of substituents, OR AN ADJACENT PAIR OF R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --COCH.dbd.C(COOH)NRh--,
Or one of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a group of formula II, ##STR2## in which Ra, Rb and Rc have the same significances as R.sub.5, R.sub.6, R.sub.7 and R.sub.8,
X is an optionally interrupted or substituted hydrocarbon chain,
Rg and Rh, which may be the same or different are each alkyl, alkenyl, phenyl-alkyl, alkanoyl, benzoyl or phenylalkanoyl,
Or Rg and R.sub.8 and/or Rh and Rc in formula II, together form a chain --(CH.sub.2).sub.n --, and n is 2, 3 or 4.
There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.

REFERENCES:
patent: 3324135 (1967-06-01), Lesher
patent: 3506667 (1970-04-01), Kaminsky
patent: 3790577 (1974-02-01), Waring
patent: 3901895 (1975-08-01), Rhomberg et al.
patent: 3932416 (1976-01-01), Bays et al.
patent: 3966743 (1976-06-01), Berger et al.
patent: 4117136 (1978-09-01), Hisada et al.
Tokuyama et al., "JACS" 89, Feb. 1967, pp. 1017-1021.
Van. Loock et al., "J. of Org. Chem.", vol. 36, No. 17, 1971, pp. 2520-2524.
Morrison et al., Organic Chemistry, 1966, pp. 273, 278-280.

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