Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-09-14
2008-08-19
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S517000
Reexamination Certificate
active
07414049
ABSTRACT:
The invention relates to 4-oxo-2,3,4,5-tetrahydro-benzo [b][1,4]diazepines of formula Iwherein R1, R2, R3and R4are as defined in the description and claims, which are γ-secretase inhibitors and which may be useful in the treatment of Alzheimer's disease.
REFERENCES:
patent: 6239131 (2001-05-01), Shinozaki et al.
patent: WO 02/083652 (2002-10-01), None
patent: WO 2004/069826 (2004-08-01), None
patent: WO 2005/023772 (2005-03-01), None
patent: WP 2005/040126 (2005-05-01), None
patent: WO06/061136 (2006-06-01), None
Sisodia, et al. Nature Reviews/Neuroscience, vol. 3, (Apr. 2002) pp. 281-290.
Beher et al., Biochemical Society Transactions (2002), vol. 30. part 4, pp. 534-537.
Wolfe, M., Current Topics in Medicinal Chemistry, 2002, 2, 371-383.
Tsai, et al., Current Medicinal Chemistry, 2002, vol. 9, No. 11, 1087-1106.
Sambamurti et al., Drug Development Research, 56, 211-227, 2002.
May, P., Drug Discovery Today, vol. 6, No. 9, May 2001, 459-462.
Nunan, et al., FEBS Letters, 483, (2000), 6-10.
Hardy, et al., Science, vol. 297, 353-356, Jul. 2002.
Wolfe, M., Journ. of Medicinal Chemistry, vol. 44, No. 13, 2001, 2039-2060.
Brockhaus et al., Neuroreport 9(7) 1481-1486 (1998).
Haass, C., The EMBO Journal (2004), 23, pp. 483-488.
Fraering, et al., Biochemistry (2004), 43 (30), pp. 9774-9789.
Herreman et al., Nature Cell Biology 2, 461-462, 2000.
De Stropper et al., Nature 398, 518-522, 1999.
Chung et al., Nature Cell Biology 3, 1129-1132, 2001.
Hadland et al., PNAS 98, 7487-7491, 2001.
Ferrando et al., Cancer Cell 1, 75-87, 2002.
Weng et al., Science 306, 269-271, 2004.
Weng et al., Mol Cell Biol 23, 655-664, 2003.
Weijzen et al., Nature Medicine 8, 979-986, 2002.
Nickoloff et al., Oncogene 22, 6598-6608, 2003.
Li et al., PNAS 97(11) 6138-6143, 2000.
Jacobs, et al, J. Med. Chem. 37, p. 1282 1994.
Szönyi et al., J. Fluorine Chemistry 55(1) p. 85, 1991.
Houston, Biochem. Pharmacol vol. 47, pp. 1469-1479, 1994.
Flohr Alexander
Jakob-Roetne Roland
Wostl Wolfgang
Hoffmann-La Roche Inc.
Johnston George W.
Kifle Bruck
Prior Kimberly J.
Rocha-Tramaloni Patricia S.
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