4- or 6-substituted aldosterones, their production and use in im

Details 4- or 6-substituted aldosterones, their production and use in im 4- or 6-substituted aldosterones, their production and use in im

1985-05-03

1987-08-11

Marantz, Sidney

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435810, 436531, 436539, 436542, 436543, 436545, 436546, 436804, 436817, G01N 33534, G01N 33535, G01N 3374

Patent

active

046861793

ABSTRACT:
A substituted aldosterone of the formula: ##STR1## wherein either one of R.sup.1 and R.sup.2 is hydrogen and the other is --S(CH.sub.2).sub.m COR.sup.3 or --OCO(CH.sub.2).sub.n COR.sup.3, provided that when R.sup.1 is hydrogen, R.sup.2 is --S(CH.sub.2).sub.m COR.sup.3 or --OCO(CH.sub.2).sub.n COR.sup.3 and when R.sup.2 is hydrogen, R.sup.1 is --S(CH.sub.2).sub.m COR.sup.3 ; m being an integer from 1 to 3, n being an integer from 1 to 5 and R.sup.3 being hydroxyl, lower alkoxy or a residue of tyramine, tyrosine lower alkyl ester, histamine, histidine, 7-aminoheptanoyltyrosine lower alkyl ester or .beta.-D-galactosidase as optionally iodinated, or its (18-20)-acetal 20,21-ketonide, which is useful as the reagent in determination of aldosterones by radioimmunoassay or enzyme immunoassay.

REFERENCES:
patent: 4277460 (1981-07-01), Kojima
patent: 4288538 (1981-09-01), Groman
patent: 4431743 (1984-02-01), Pang
patent: 4477577 (1984-10-01), Nakamura
Chemical Abstracts I, 100: 169115k (1984).
Chemical Abstracts II, 101: 17491n (1984).

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