4(Or 5)-(pyridinyl)-2-pyrimidinamines and cardiotonic use thereo

Details 4(Or 5)-(pyridinyl)-2-pyrimidinamines and cardiotonic use thereo 4(Or 5)-(pyridinyl)-2-pyrimidinamines and cardiotonic use thereo

1983-07-25

1985-04-23

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544331, A61K 31505, C07D23924

Patent

active

045129932

ABSTRACT:
Shown are 2-(NB)-4-PY-5-Q-pyrimidines (I) and 2-(NB')-5-PY-4-Q'-pyrimidines (II) or salts thereof, where PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents, Q and Q' are each hydrogen or methyl, NB is dimethylamino or N-(2-hydroxyethyl)methylamino and NB' is amino, dimethylamino, acetylamino or propionylamino; the preparation thereof; and, their cardiotonic use.

REFERENCES:
patent: Re30024 (1979-06-01), Lesher et al.
patent: 4086233 (1978-04-01), Lesher et al.
patent: 4118571 (1978-10-01), Lesher et al.
Bennett et al., Journal Medicinal Chemistry, 1978, vol. 21, No. 7, pp. 623-628.

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