4- or 5-Nitroimidazoles and processes for their manufacture

Details 4- or 5-Nitroimidazoles and processes for their manufacture 4- or 5-Nitroimidazoles and processes for their manufacture

1974-11-11

1976-12-07

Love, Ethel G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260243B, 260243R, 260247, 260248AS, 260248NS, 260250A, 260250R, 2602564R, 2602937, 260296R, 260302D, 260302F, 260302H, 2603067R, 260307R, 2603096, 424246, 424251, 424263, 424264, 424272, 424273, 424274, 424275, 424285, C07D 4934

Patent

active

039962385

ABSTRACT:
4- or 5-nitro-imidazoles of the formula I ##SPC1##
wherein one of the radicals R.sub.1 and R.sub.2 is hydrogen or lower alkyl and R.sub.2 is the nitro group or R.sub.1 is the nitro group and R.sub.2 is hydrogen or lower alkyl, R.sub.3 is lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, lower alkylsulphonyl-lower alkyl, dilower alkylamino-lower alkyl, lower alkylene-amino-lower alkyl, lower oxaalkyleneamino-lower alkyl, lower thiaalkyleneamino-lower alkyl or lower azaalkyleneamino lower alkyl, R.sub.4 is oxo or thioxo and R.sub.5 is a phenyl radical which optionally has one, two or more substituents, an optionally substituted furyl, thienyl, pyrrolyl, indolyl, oxazolyl, thiazolyl, thiadiazolyl, 4,5-dihydro-thiazolyl-(2), tetrahydro-thiazolyl-(2), pyrazolyl, indazolyl, imidazolyl-(5), imidazolyl-(4), pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, 1,3,5- or 1,2,4-triazinyl, pyrrolidinyl, pyrazolinyl, indolinyl, pyrazolidinyl, imidazolinyl, imidazolidinyl, piperidyl, morpholinyl, thiazinyl, thiomorpholinyl or piperazinyl radical, an optionally C-lower alkylated pyrrolidino, piperidino, morpholino, thiomorpholino, piperazino, N'-lower alkyl-piperazino, N'-.beta.-hydroxyethyl-piperazino or pyridinium radical and R.sub.6 and R.sub.7 independently of one another denote hydrogen or lower alkyl or conjointly form the missing part of a fused benzene nucleus which is optionally substituted by lower alkyl, lower alkoxy, halogen, trifluoromethyl and/or nitro, as well as their S-oxides, sulphones N-oxides and/or acid addition salts thereof, which are useful as agents against schistosomes, filaria, trichomonades, bacteriae, and/or amoebae.

REFERENCES:
patent: 3832352 (1974-08-01), Ilvespaa

Affiliated with

Also associated with

Rating

4- or 5-Nitroimidazoles and processes for their manufacture does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4- or 5-Nitroimidazoles and processes for their manufacture, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4- or 5-Nitroimidazoles and processes for their manufacture will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-379153