4(or 3)-(3,4-Dihydroxyphenyl)pyridines, their cardiotonic use an

Details 4(or 3)-(3,4-Dihydroxyphenyl)pyridines, their cardiotonic use an 4(or 3)-(3,4-Dihydroxyphenyl)pyridines, their cardiotonic use an

1980-08-04

1981-11-24

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546344, C07D21330, A61K 3144

Patent

active

043024629

ABSTRACT:
4(or 3)-(3,4-Dihydroxyphenyl)pyridine, a cardiotonic agent, is prepared by demethylating 4(or 3)-(3,4-dimethoxyphenyl)pyridine, preferably by heating with aqueous hydrogen bromide. 4(or3)-[3,4-di-(OR)-phenyl]pyridine, where R is hydrogen or methyl, or pharmaceutically-acceptable acid-addition salt thereof is disclosed as the active component in a cardiotonic composition for increasing cardiac contractility and in the method for increasing cardiac contractility in a patient requiring such treatment. The novel isomeric 2-[3,4-di-(OR)-phenyl]pyridine, where R is hydrogen or methyl, is shown for comparative purposes.

REFERENCES:
patent: 3575985 (1971-04-01), Ritchie et al.
Ginos et al., Journal of Medicinal Chemistry, vol. 18, No. 12, pp. 1194-1200, (1975).
Coates et al., Journal of the Chemical Society, London, 1943, pp. 406-413.

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