4"-O-sulfonyl erythromycin-9-O-oxime derivatives

Details 4"-O-sulfonyl erythromycin-9-O-oxime derivatives 4"-O-sulfonyl erythromycin-9-O-oxime derivatives

1975-06-12

1977-12-13

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, C07H 1708, A61K 3170

Patent

active

040630145

ABSTRACT:
A 4"-O-sulfonyl erythromycin derivative of the following structural formula: ##STR1## where R is selected from the group consisting of oxygen, oxime, and substituted oxime, R.sub.1 is hydrogen or hydroxy and R.sub.2 is selected from the group consisting of phthalimide, substituted amides, benzamides, substituted benzamides, sulfonamides, substituted sulfonamides, amines, substituted amines, phenylurea, substituted phenylurea, phenylthiourea, substituted phenylthiourea, thiophenol and substituted thiophenol, phenoxides and substituted phenoxides and R.sub.3 is hydrogen or methyl. The present sulfonyl derivatives of erythromycin A, B and C are useful as antibiotics.

REFERENCES:
patent: 3836819 (1974-09-01), Hallas et al.
patent: 3869445 (1975-03-01), Hallas et al.

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