4-O-(2,3,5-Trideoxy-5-amino-.alpha.-D-pentofuranosy l)-6-O-amino

Details 4-O-(2,3,5-Trideoxy-5-amino-.alpha.-D-pentofuranosy l)-6-O-amino 4-O-(2,3,5-Trideoxy-5-amino-.alpha.-D-pentofuranosy l)-6-O-amino

1978-11-08

1980-07-15

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

2603477, 536 10, 536 17R, A61K 3171, C07H 1522

Patent

active

042128609

ABSTRACT:
4-O-(2,3,5-Trideoxy-5-amino-.alpha.-D-pentofuranosyl)-6-O-aminoglycosyl-1,3 -diaminocyclitols and 1-N-substituted derivatives thereof are described together with methods for their preparation and their use as antibacterial agents.
Preferred are 1-N-(.omega.-amino-.alpha.-hydroxyalkanoyl)-[4-O-(2,3,5-trideoxy-5-amino-. alpha.-D-pentofuranosyl)-6-O-garosaminyl-2-deoxystreptamines], particularly the 1-N-(S-.beta.-amino-.alpha.-hydroxypropionyl) derivatives, which are broad spectrum antibacterial agents.

REFERENCES:
patent: 3049552 (1962-08-01), Garber
patent: 3268560 (1966-08-01), Heying
patent: 4065616 (1977-12-01), Umezawa et al.
patent: 4101556 (1978-07-01), Kavadias et al.
Kugelman et al. Reprint from "Jour. of the Chem. Soc." Perkins Transactions I, 1976, pp. 1097-1113.
Mallams et al. Reprint from "Jour. of the Chem. Soc." Perkins Transactions I, 1976, pp. 1135-1146.

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