4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatm

Details 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatm 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatm

1990-06-29

1991-08-20

Rivers, Diana

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514265, 514266, 544276, 544277, 544313, 544314, 544317, A61K 3152, A61K 31505, C07D40504, C07D47300

Patent

active

050414496

ABSTRACT:
There are provided novel 2-substituted-4-substituted-1,3-dioxolanes which are particularly useful as antiviral agents.

REFERENCES:
patent: 4041037 (1977-08-01), Dvonch et al.
patent: 4415573 (1983-11-01), Ochi et al.
patent: 4960773 (1990-10-01), Korbonits et al.
Norbeck, et al., Chemical Abstracts, vol. 113(3):24406q (1990).
Mitsuya et al., "3'-Azido 3'-Deoxythymidine (BW A509U): An Antiviral Agent that Inhibits the Infectivity and Cytopathic Effect of Human T-Lymphotropic Virus Type III/Lymphadenopathy-Associated Virus In Vitro", Proc. Natl. Acad. Sci., U.S.A., 82, pp. 7096-7100 (1985).
Mitsuya et al., "Inhibition of the In Vitro Infectivity and Cytopathic Effect of Human T-Lymphotropic Virus Type III/Lymphadenopathy-Associated Virus (HTLV-III/LAV) by 2', 3'-Dideoxynucleosides", Proc. Natl. Acad. Sci. U.S.A., 83, pp. 1911-1915 (1986).
Balzarini et al., "Potent and Selective Anti-HTLV-III/LAV Activity of 2',3'-Dideoxycytidinene, the 2',3'-Unsaturated Derivative of 2',3'-Dideoxycytidine", Biochemical and Biophysical Research Communications, 140 (2), pp. 735-742 (1986).
Baba et al., "Both 2',3'-Dideoxythymidine and its 2',3'-Unsaturated Derivative (2',3'-Dideoxythymidinene) are Potent and Selective Inhibitors of Human Immunodefficiency Virus Replication In Vitro", Biochemical and Biophysical Research Communications, 142(1), pp. 128-134 (1987).
Lin et al., "Synthesis and Antiviral Activity of Various 3'-Azido, 3'-Amino, 2',3'-Unsaturated, and 2',3'-Dideoxy Analogues of Pyrimidine Deoxyribonucleosides Against Retroviruses", J. Med. Chem., 30, pp. 440-444 (1987).
Herdewijn et al., "3'-Substituted 2',3'-Dideoxynucleoside Analogues as Potential Anti-HIV (HTLV-III/LAV) Agents", J. Med. Chem., 30, pp. 1270-1278 (1987).
Hallonquist et al., "Studies on Reactions Relating to Carbohydrates and Polysaccharides", Canadian Journal of Research, 7, pp. 129-136 (1933).
Corey et al., "Useful Procedures for the Oxidation of Alcohols Involving Pyridinium Dichromate in Aprotic Media", Tetrahedron Letters, 5, pp. 399-402 (1979).
Barton et al., "Transformations of Penicillin. Part III. A New Route to 2,2-Dimethyl-6.alpha.-Phenylacetamidopenam'.alpha.-Ols-Oxide and its Esters; O-NitroBenzoate as a Protecting Group for Alcohols and Phenols", J. Chem. Soc. Perkin I, pp. 599-603 (1973).
Wise et al., "Replacement of the 2-and 4-Oxo Groups of Uridine by a Seleno Group", Nucleic Acid Chemistry, pp. 413-419 (1978).
Ueda et al., "Synthesis and Optical Properties of 2,3-Dideoxy-D-Erythro-Hex-2-Enopyranosyl Nucleosides (Nucleosides and Nucleotides, LXII.sup.1)", Chem. Pharm. Bull., 33(9), pp. 3689-3695 (1985).
Gosselin et al., "Systematic Synthesis and Biological Evaluation of .alpha.- and .beta.-D-Lyxofuranosyl Nucleosides of the Five Naturally Occurring Nucleic Acid Bases", J. Med. Chem., 30, pp. 982-991 (1987).

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