4-Nitroperhydropyrido[1,2-a][1,4]diazepines

Details 4-Nitroperhydropyrido[1,2-a][1,4]diazepines 4-Nitroperhydropyrido[1,2-a][1,4]diazepines

1974-09-20

1976-06-22

Todd, G. Thomas

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424267, C07D47102

Patent

active

039651037

ABSTRACT:
Compounds of the formula v,2/12
Wherein R.sub.1 is H, lower-alkyl, hydroxyalkyl, phenyl, aralkyl, or --(CH.sub.2) .sub.n --X wherein n is 0-4 and X is --COO-lower-alkyl, C.tbd.N or --COOH and R.sub.2 is H, lower-alkyl or aralkyl, produced by condensing a diamine of the formula ##SPC1##
With a nitro compound of the formula R.sub.1 --CH.sub.2 --NO.sub.2 in the presence of formalin or paraformaldehyde, or with the R.sub.1 -- C(CH.sub.2 OH).sub.2 NO.sub.2 reaction product of the above nitro compound and formalin or paraformaldehyde, or with formalin or paraformaldehyde followed by reaction with the above nitro compound, and their acid addition salts, possess antimicrobial activity against both gram-positive and gram-negative bacteria and also against dermatophytes, yeasts and other fungi.

REFERENCES:
patent: 3531485 (1970-09-01), Freed

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