4"-N-(Substituted)-apramycin antibiotic derivatives and intermed

Details 4"-N-(Substituted)-apramycin antibiotic derivatives and intermed 4"-N-(Substituted)-apramycin antibiotic derivatives and intermed

1981-12-24

1982-11-23

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, C07H 1522

Patent

active

043606652

ABSTRACT:
Apramycin derivatives substituted at the 4"-amino group with a variety of substituents are broad spectrum antibiotics. Also claimed are intermediates in the synthesis of these apramycin derivatives.

REFERENCES:
patent: 3691279 (1972-09-01), Thompson et al.
patent: 3853709 (1974-12-01), Stark
patent: 3876767 (1975-04-01), Ose
O'Connor et al., "Chem. Abst.", vol. 85, 1976, p. 21,760(t).
S. Nakagawa et al., J. Antibiotics (Tokyo), 31, 675 (1978).
K. Richardson et al., J. Antibiotics (Tokyo), 30, 843 (1977).
A. Fujii et al., J. Antibiotics (Tokyo), 21, 340 (1968).
M. B. Thomas and M. T. Williams, Tetrahedron Lett., 21, 4981 (1980).
E. Akita et al., J. Antibiotics (Tokyo), 26, 365 (1973).
Y. Abe et al., J. Antibiotics (Tokyo), 34, 1434 (1981).

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