Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1989-08-02
1991-02-26
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540450, 540609, 544162, 544400, 546233, 546242, 548567, 548569, 548950, 548967, 558232, 560 27, 560 29, 560 30, 560 31, 560 32, 560 33, 560159, 514315, 514331, 514428, 514478, 5142378, 514255, 514484, 514487, 514488, 514489, 514490, A61K 31395, C07D22304
Patent
active
049962019
ABSTRACT:
4-(N-Substituted amino)-2-butynyl-1-carbamates and thiocarbamates and derivatives thereof are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as centrally acting muscarinic agents and are useful as analgesic agents for the treatment of pain, as sleep aids and as agents for treating the symptoms of senile dementia, Alzheimer's disease, Huntington's chorea, tardive dyskinesia, hyperkinesia, mania, or similar conditions of cerebral insufficiency characterized by decreased cerebral acetylcholine production or release.
REFERENCES:
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patent: 4065471 (1977-12-01), Dickinson
Chemical Abstracts 106: 137654E "Synthesis of vicinal Amino Carbamate of acetylenes," (1987).
M. V. Mavrov, et al., Izvestiya Akademii Nauk SSR, Seriya Khimicheskaya, vol. 7, pp. 1568-1571 (196), Eng. trans.
Journal of Medicinal Chemistry, 10:615 (1967) Neumeyer, et al, Pharmacologically Active Acetylene Compounds, I. Structural Modifications of Oxotremorine.
Brit. J. Pharmacol. (1966), 26,56-67 A30 A. Bebbington, et al The Central and Peripheral Activity of Acetylenic Amines Related to Oxotremorine.
Bergmeier Stephen C.
Kester Jeffrey A.
Moos Walter H.
Tecle Haile
Thomas Anthony J.
Raymond Richard L.
Russell Mark W.
Tinney Francis J.
Warner-Lambert Co.
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