4-N-Acylfortimicin B derivatives and the chemical conversion of

Details 4-N-Acylfortimicin B derivatives and the chemical conversion of 4-N-Acylfortimicin B derivatives and the chemical conversion of

1979-01-10

1980-11-04

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

536 17R, C07C10352, C07H 1522

Patent

active

042319242

ABSTRACT:
This invention provides 4-N-acylfortimicin B derivatives of the structure ##STR1## wherein R is acyl, aminoacyl, N-monoloweralkylminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, or substituted aminoacyl of the formula ##STR2## where R.sup.1 is an acyl radical derived from an amino acid or a short peptide, and the pharmaceutically acceptable salts thereof.
The compounds are useful as intermediates for preparing 4-N-alkyl or substituted alkylfortimicin B derivatives. In addition to their utility as intermediates, some of the compounds of this invention are also useful as antimicrobial agents.

REFERENCES:
patent: 3808198 (1974-04-01), Nalto et al.
patent: 3974137 (1976-08-01), Schreiber et al.
Chem. Abstr. vol. 83, 1975 pp. 43691g.
Chem. Abst. vol. 83, 1975 pp. 147705f.

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