4-N-acylfortimicin B derivatives and the chemical conversion of

Details 4-N-acylfortimicin B derivatives and the chemical conversion of 4-N-acylfortimicin B derivatives and the chemical conversion of

1976-09-23

1978-05-23

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125R, 424177, 424118, 2603457R, 424283, C07D30922

Patent

active

040910326

ABSTRACT:
This invention provides 4-N-acylfortimicin B derivatives of the structure ##STR1## wherein R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, or substituted aminoacyl of the formula ##STR2## where R.sup.1 is an acyl radical derived from an amino acid or a short peptide, and the pharmaceutically acceptable salts thereof.
The compounds are useful as intermediates for preparing 4-N-alkyl or substituted alkylfortimicin B derivatives. In addition to their utility as intermediates, some of the compounds of this invention are also useful as antimicrobial agents.

REFERENCES:
patent: 3931400 (1976-01-01), Nara et al.
patent: 3976768 (1976-08-01), Nara et al.
Nara, et al., Chem. Abst. 84, 1976, p. 162885d.

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