4-N-acylfortimicin B derivatives and the chemical conversion of

Details 4-N-acylfortimicin B derivatives and the chemical conversion of 4-N-acylfortimicin B derivatives and the chemical conversion of

1978-11-01

1979-11-06

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603459R, 424177, C07C10352, C07D30922, A61K 3700

Patent

active

041735641

ABSTRACT:
This invention provides 4-N-acylfortimicin B derivatives of the structure ##STR1## wherein R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, or substituted aminoacyl of the formula ##STR2## where R.sup.1 is an acyl radical derived from an amino acid or a short peptide, and the pharmaceutically acceptable salts thereof.
The compounds are useful as intermediates for preparing 4-N-alkyl or substituted alkylfortimicin B derivatives. In addition to their utility as intermediates, some of the compounds of this invention are also useful as antimicrobial agents.

REFERENCES:
patent: 3931400 (1976-01-01), Nara et al.

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