Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1977-12-21
1980-01-15
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
536 17R, 536 4, A61K 3171, C07H 1522
Patent
active
041839200
ABSTRACT:
4-N-Acyl, 2'-N-acyl and 4,2' -N,N' -diacylfortimicin E derivatives represented by the formula ##STR1## wherein R is hydrogen, acyl, aminoacyl, N-lower alkylamino acyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl or an amino acid residue; R.sub.1 is hydrogen, acyl, aminoacyl, N-loweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl or an amino acid residue, with the limitation that R cannot be hydrogen when R.sub.1 is hydrogen, and R.sub.1 cannot be hydrogen when R is hydrogen; the pharmaceutically acceptable salts thereof; intermediates therefor; pharmaceutical compositions; and methods of making and using the compounds. The compounds are useful as antibiotics.
REFERENCES:
patent: 3931400 (1976-01-01), Nara et al.
patent: 3976768 (1976-08-01), Nara et al.
patent: 3985727 (1976-10-01), Daniels
Kurath Paul
Martin Jerry R.
Tadanier John S.
Abbott Laboratories
Brown Johnnie R.
Fato Gildo E.
Niblack Joyce R.
Niblack Robert L.
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