4-(M-benzoylphenyl)butyric acid derivatives

Details 4-(M-benzoylphenyl)butyric acid derivatives 4-(M-benzoylphenyl)butyric acid derivatives

1972-08-29

1976-01-06

Patten, James A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260141, 260465R, 260475SC, 2605011, 26050111, 26050112, 26050121, 260544M, 260591, 260618, 424278, 424308, 424309, 424310, 424317, 424319, C07C 6522

Patent

active

039313026

ABSTRACT:
Novel butyric acid derivatives of the formula ##SPC1##
Wherein X, X.sub.1, X.sub.2 and X.sub.3 are individually selected from the group consisting of hydrogen, halogen, lower alkyl of 1 to 5 carbon atoms, lower alkoxy of 1 to 5 carbon atoms, lower alkylthio of 1 to 5 carbon atoms, trifluoromethoxy, trifluoromethylthio, trifluoromethyl, OH and dilower alkylamino of 1 to 5 carbon atoms for each alkyl, R is selected from the group consisting of hydrogen, lower alkyl of 1 to 5 carbon atoms, o-carboxyphenyl, 2,3-dihydroxypropyl and -CH.sub.2 -CH - CH.sub.2 ##EQU1## wherein P and Q are individually lower alkyl of 1 to 5 carbon atoms, Z and X.sub.4 are individually selected from the group consisting of hydrogen and lower alkyl of 1 to 5 carbon atoms and Y is selected from the group consisting of hydrogen and --OH and the dotted line indicates the optional presence of a double bond when Y is hydrogen and when R is hydrogen or o-carboxyphenyl, the salts thereof with a non-toxic pharmaceutically acceptable mineral or organic base, which compounds have anti-inflammatory and analgesic activity and are substantially devoid of ulcerigenic activity and their preparation and novel intermediates formed therein.

REFERENCES:
patent: 3652666 (1972-03-01), Farge et al.
patent: 3741988 (1973-06-01), Allais et al.

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