Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1978-08-14
1979-11-13
Berch, Mark L.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
546183, 560171, C07D20508
Patent
active
041743164
ABSTRACT:
Disclosed is a process for preparing 7-(1-hydroxethyl)-3-(2-aminoethylthio)-1-carbadethiaceph-3-em-3-carboxylic acid and its pharmaceutically acceptable salts and esters (I) by total synthesis starting with L-aspartic acid and proceeding via intermediates II and IIa (4-iodomethylazetidin-2-one): ##STR1##
REFERENCES:
Clauss, Chem. Abs. 81, 77753c, (1974).
Christensen Burton G.
Ratcliffe Ronald W.
Salzmann Thomas N.
Arno James A.
Berch Mark L.
Levitt Julian S.
Merck & Co. , Inc.
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