4-imidazolyl substituted pyrimidine derivatives with CDK...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S255050, C514S275000, C544S122000, C544S331000

Reexamination Certificate

active

07442697

ABSTRACT:
Compounds of the formula (I): wherein R1, R2, R3, R4, R5and p are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-blooded animal, such as man.

REFERENCES:
patent: 4983608 (1991-01-01), Effland et al.
patent: 5516775 (1996-05-01), Zimmermann et al.
patent: 5521184 (1996-05-01), Zimmermann
patent: 5610303 (1997-03-01), Kimura et al.
patent: 5739143 (1998-04-01), Adams et al.
patent: 5859041 (1999-01-01), Liverton et al.
patent: 6835726 (2004-12-01), Cushing et al.
patent: 6908920 (2005-06-01), Thomas et al.
patent: 6969714 (2005-11-01), Breault et al.
patent: 2003/0144303 (2003-07-01), Hawley et al.
patent: 2003/0191307 (2003-10-01), Blumenkopf et al.
patent: 2004/0102630 (2004-05-01), Brumby et al.
patent: 2004/0224966 (2004-11-01), Brumby et al.
patent: 2005/0176743 (2005-08-01), Luecking et al.
patent: 2006/0079543 (2006-04-01), Sum et al.
patent: 2006/0111378 (2006-05-01), Cleve et al.
patent: 2231765 (1998-09-01), None
patent: 0 135 472 (1985-03-01), None
patent: 0 363 002 (1990-04-01), None
patent: 0 379 806 (1990-08-01), None
patent: 0 945 443 (1999-09-01), None
patent: 1056742 (2003-07-01), None
patent: 220630 (2002-03-01), None
patent: 91/18887 (1991-12-01), None
patent: 92/20642 (1992-11-01), None
patent: 95/09847 (1995-04-01), None
patent: 95/09851 (1995-04-01), None
patent: 95/09852 (1995-04-01), None
patent: 95/09853 (1995-04-01), None
patent: 95/15952 (1995-06-01), None
patent: 96/05177 (1996-02-01), None
patent: 96/28427 (1996-09-01), None
patent: 96/40143 (1996-12-01), None
patent: 97/19065 (1997-05-01), None
patent: 97/35856 (1997-10-01), None
patent: 97/40017 (1997-10-01), None
patent: 97/44326 (1997-11-01), None
patent: 97/47618 (1997-12-01), None
patent: 98/11095 (1998-03-01), None
patent: 98/16230 (1998-04-01), None
patent: 98/18782 (1998-05-01), None
patent: 98/25619 (1998-06-01), None
patent: 98/33798 (1998-08-01), None
patent: 98/41512 (1998-09-01), None
patent: 98/54093 (1998-12-01), None
patent: 98/56788 (1998-12-01), None
patent: 99/01136 (1999-01-01), None
patent: 99/32121 (1999-01-01), None
patent: 99/18096 (1999-04-01), None
patent: 99/18942 (1999-04-01), None
patent: 99/31073 (1999-06-01), None
patent: 99/41253 (1999-08-01), None
patent: 99/50250 (1999-10-01), None
patent: 99/50251 (1999-10-01), None
patent: 00/12485 (2000-03-01), None
patent: 00/12486 (2000-03-01), None
patent: 00/17202 (2000-03-01), None
patent: 00/17203 (2000-03-01), None
patent: 00/21926 (2000-04-01), None
patent: 00/25780 (2000-05-01), None
patent: 00/26209 (2000-05-01), None
patent: 00/39101 (2000-06-01), None
patent: 00/44750 (2000-08-01), None
patent: 00/49018 (2000-08-01), None
patent: 00/53595 (2000-09-01), None
patent: 00/55161 (2000-09-01), None
patent: 00/59892 (2000-10-01), None
patent: 00/78731 (2000-12-01), None
patent: 01/14375 (2001-03-01), None
patent: 01/29009 (2001-04-01), None
patent: 01/30778 (2001-05-01), None
patent: 01/37835 (2001-05-01), None
patent: 01/47897 (2001-07-01), None
patent: 01/47921 (2001-07-01), None
patent: 01/60816 (2001-08-01), None
patent: 01/64653 (2001-09-01), None
patent: 01/64654 (2001-09-01), None
patent: 01/64655 (2001-09-01), None
patent: 01/64656 (2001-09-01), None
patent: 01/72717 (2001-10-01), None
patent: 02/04429 (2002-01-01), None
patent: 02/20512 (2002-03-01), None
patent: WO 02/046170 (2002-06-01), None
patent: WO 02/046171 (2002-06-01), None
patent: 02/066481 (2002-08-01), None
patent: WO 02/065979 (2002-08-01), None
patent: WO 02/066480 (2002-08-01), None
patent: WO 02/092573 (2002-11-01), None
patent: 02/096887 (2002-12-01), None
patent: WO 02/096888 (2002-12-01), None
patent: 03/007955 (2003-01-01), None
patent: WO 03/011837 (2003-02-01), None
patent: WO 03/029249 (2003-04-01), None
patent: WO 03/031446 (2003-04-01), None
patent: WO 03/037891 (2003-05-01), None
patent: 03/076433 (2003-09-01), None
patent: 03/076435 (2003-09-01), None
patent: 03/076436 (2003-09-01), None
patent: WO 2004/005283 (2004-01-01), None
patent: WO 2004/043467 (2004-05-01), None
patent: WO 2004/043953 (2004-05-01), None
patent: WO 2004/087698 (2004-10-01), None
patent: WO 2004/087699 (2004-10-01), None
patent: WO 2004/101549 (2004-11-01), None
patent: WO 2004/101564 (2004-11-01), None
patent: WO 2005/012298 (2005-02-01), None
patent: WO 2005/037800 (2005-04-01), None
patent: WO 2005/075461 (2005-08-01), None
patent: WO 2005/075468 (2005-08-01), None
patent: WO 2005/113550 (2005-12-01), None
patent: WO 2005/116025 (2005-12-01), None
patent: WO 2006/034872 (2006-04-01), None
patent: WO 2006/044509 (2006-04-01), None
patent: WO 2006/050076 (2006-05-01), None
patent: WO 2006/064251 (2006-06-01), None
patent: WO 2006/075152 (2006-07-01), None
patent: WO 2006/095159 (2006-09-01), None
patent: WO 2007/015064 (2007-02-01), None
patent: WO 2007/036732 (2007-04-01), None
patent: WO 2007/040440 (2007-04-01), None
patent: WO 2007/138268 (2007-12-01), None
patent: WO 2007/138277 (2007-12-01), None
patent: WO 2007/148070 (2007-12-01), None
Traxler, Protein tyrosine kinase inhibitors in cancer treatment, Expert Opinion on Therapeutic Patents, 7(6), pp. 571-588, 1997.
Lu Valle et al., Cell Cycle Control in Growth Plate Chondrocytes, Frontiers in Biosciences 5, d493-503, May 2000.
Boschelli et al., Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8-H-pyrido[2,3-d]pyrimidines: Identifidation of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors, J. Med. Chem., vol. 41, 1998, pp. 4365-4377.
Deady et al., “Reactions of some Quinazoline Compounds with Ethoxymethylenemalonic Acid Derivatives”, J. Heterocyclic Chem., vol. 26, 1989, pp. 161-168.
El-Kerdawy et al.; “2,4-Bis (Substituted)-5-Nitropyrimidines of Expected Diuretic Action”; Egypt J. Chem. vol. 29, No. 2, 1986, pp. 247-251.
Fiziol Akt Veshchestva, 1975, vol. 7, pp. 68-72.
Ghosh et al.; “2,4-Bis(arylamino)-5-methylpyrimidines as Antimicrobial Agents”; J. Med. Chem., 1967, vol. 10, No. 5, pp. 974-975.
Ghosh, “2,4-Bis(Arylamino)-6-Methyl Pyrimidines as Antimicrobial Agents”, J. Indian Chem. Soc., vol. 58, No. 5, 1981, pp. 512-513.
Schmidt et al.; “A Convenient Synthesis of 2-substituted 4-Amino-5-pyrimidinecarbonitriles”; J. Heterocycle Chem., 1997, vol. 24, No. 5, pp. 1305-1307.
Zimmermann et al., Phenylamino-Pyrimidine (PAP) Derivatives: A New Class of Potent and Selective Inhibitors of Protein Kinase C (PKC), Arch. Pharm. Pharm. Med. Chem., vol. 329, 1996, pp. 371-376.
Blain et al. “Differential Interaction of the Cyclin-dependent Kinase (Cdk) inhibitor p27Kip1 with Cyclin A-Cdk2 and Cyclin D2-Cdk4” J. Biol. Chem. 272(41): 25863-25872 (1997).
Simone, Oncology: Introduction, Cecil Textbook of Medicine, 20th Edition, vol. 1, pp. 1004-1010 (1996).
Volin et al. “Cell cycle implications in the pathogenesis of rheumatoid arthritis” Frontiers in Bioscience 5: D594-601(2000).
Fiziol Akt Veshchestva 7:68-72 (1975) (Translation enclosed).

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