Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-10-04
2005-10-04
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S256000, C544S333000
Reexamination Certificate
active
06951864
ABSTRACT:
The invention provides 4-imidazol-1-ylmethyl pyrimidine of the formulathat bind to GABAAreceptors. In the above formula, R1, R2R3, R4, R5, R6and Ar are defined herein. Such compounds may be used to modulate ligand binding to GABAAreceptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals, and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAAreceptors (e.g., receptor localization studies).
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Han Bingsong
Maynard George D.
Xie Linghong
Xu Yuelian
Fidel Seth A.
Kadlecek Ann T.
Neurogen Corp.
Rao Deepak
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