4-hydroxythiazoles as 5-lipoxygenase inhibitors

Details 4-hydroxythiazoles as 5-lipoxygenase inhibitors 4-hydroxythiazoles as 5-lipoxygenase inhibitors

1990-07-18

1992-06-23

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546280, 548182, 548189, 548165, 548170, A61K 31425, C07D27714, C07D27722

Patent

active

051243423

ABSTRACT:
A composition for the inhibition of lipoxygenase enzymes comprising a pharmaceutically acceptable carrier and a compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are independently selected from the group consisting of alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, arylalkenyl, reduced heteroaryl, and reduced heteroarylalkyl and substituted derivatives thereof having one or more substituents independently selected from the group consisting of halogen, alkyl, halosubstituted alkyl, aryl, arylalkyl, reduced heteroaryl, arylalkoxy, cyano, nitro, COR.sub.4, SO.sub.2 R.sub.4, NR.sub.5 R.sub.6, OR.sub.6, COCX.sub.1 X.sub.2 NR.sub.6 R.sub.7, CON(OH)R.sub.6, NR.sub.6 COR.sub.4, CR.sub.5 (NH.sub.2)CO.sub.2 R.sub.5, NHCX.sub.1 X.sub.2 CO.sub.2 R.sub.5, N(OH)CONR.sub.5 R.sub.6, N(OH)COR.sub.4, NHCONR.sub.5 R.sub.6, C(NOH)NHOH and CONHNR.sub.5 R.sub.6 ;

REFERENCES:
patent: 4935424 (1980-06-01), Caprathe et al.

Affiliated with

Also associated with

Rating

4-hydroxythiazoles as 5-lipoxygenase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4-hydroxythiazoles as 5-lipoxygenase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-hydroxythiazoles as 5-lipoxygenase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-933023