4-hydroxypyridine derivatives, useful for treating circulatory d

Details 4-hydroxypyridine derivatives, useful for treating circulatory d 4-hydroxypyridine derivatives, useful for treating circulatory d

1991-12-13

1993-06-29

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546296, 4352535, A61K 3144, C07D21369, C12N 120

Patent

active

052235190

ABSTRACT:
4-Hydroxypyridine derivative represented by the following formula ##STR1## wherein R represents a methyl group or an isopropyl group, and the method for preparing the derivative comprising the step of cultivating a strain belonging to Streptomyces karnatakensis are disclosed. Also disclosed are the pharmaceutical composition comprising the same and a method for treating circulatory diseases comprising the step of administering said compound to a patient.

REFERENCES:
Yano, et al., "Actinopyrones A,B and C, new physiologically active substances. II. Physicochemical properties and chemical structures", Chemical Abstracts, vol. 105, No. 25, Dec. 1986, p. 747, col. 1, 226123r.
Jansen, et al., "Revised stereochemistry for pipericidin A.sub.1 ", Chemical Abstracts, vol. 100, No. 15, Apr. 1984, p. 561, col. 2, 120743z.
Yoshida, et al., "The structural revision of pipericiden A by combination of CMR spectroscopic and biosynthetic studies", Chemical Abstracts, vol. 87, No. 5, Aug. 1977, p. 497, col. 1, 39240z.

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