Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-07-18
2006-07-18
Bernhardt, Emily (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S252120, C514S252130, C514S254010, C514S617000, C514S622000, C544S372000, C544S379000, C544S391000, C544S401000, C564S170000
Reexamination Certificate
active
07078407
ABSTRACT:
The present invention relates to 4-hydroxycinnamamide derivatives as antioxidants and pharmaceutical compositions containing them. More particularly, it relates to 4-hydroxycinnamamide derivatives showing superior antioxidant activity compared to the known antioxidant compounds, their pharmaceutically acceptable salt, and pharmaceutical compositions containing them. It can be usefully used in treating neurodegerative diseases such as aging, cancer, diabetes, ischemic stroke, Parkin's disease, dementia and Huntinton's disease.
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Bebbington, David, et al., 3,5-Disubstituted-4-hydroxyphenyls Linked to 3-Hydroxy-2-methyl-4(1H)-pyridinone: Potent Inhibitors of Lipid Peroxidation and Cell Toxicity, J. Med. Chem. 2000, 43, 2779-2782.
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Rajan, Padinchare, et al., Synthesis and Evaluation of Caffeic Acid Amides as Antioxidants, Bioorganic & Medicinal Chemistry Letters 11 (2001) 215-217.
Jung Young-Sik
Kong Jae-Yang
Lim Hee-Jong
Park No-Sang
Park Woo-Kyu
Bernhardt Emily
Korea Research Institute of Chemical Technology
Lucas & Mercanti LLP
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