4-(Hydroxy-substituted-amino)-furo[3,2-c]pyridines

Details 4-(Hydroxy-substituted-amino)-furo[3,2-c]pyridines 4-(Hydroxy-substituted-amino)-furo[3,2-c]pyridines

1974-07-26

1976-03-02

Coughlan, Jr., Paul M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424256, C07D40504

Patent

active

039417972

ABSTRACT:
Disclosed are compounds of the class of furo[3,2-c]pyridines substituted at the 4-position by an amino function bearing a hydroxy-alkyl nitrate moiety, e.g., 4-[ 4-(2-hydroxyethyl)-1-piperazino]-furo[3,2-c]pyridine nitrate. The compounds have pharmacological activity in animals and are useful, for example, as anti-anginal agents. Also disclosed are the corresponding hydroxy intermediates which are useful in preparation of the nitrates and also as anti-anginal agents or as agents in the treatment of shock.

REFERENCES:
patent: 3637700 (1972-01-01), Gabel et al.
patent: 3853877 (1974-12-01), Simpson
Bourzat et al. Bull. Soc. Chim. de France, 1971, No. 5, pp. 1727-1730.

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