4-Hydroxy pyrrolidin-2-onyl-amides

Details 4-Hydroxy pyrrolidin-2-onyl-amides 4-Hydroxy pyrrolidin-2-onyl-amides

1978-02-08

1978-11-07

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424274, C07D20728

Patent

active

041245946

ABSTRACT:
Pyrrolidine derivatives of the formula ##STR1## are prepared from .gamma.-amino-.beta.-hydroxybutyric acid which, after reaction with a silylating agent, is reacted, in the presence of an acid acceptor, with a halogen derivative of an ester of an aliphatic acid and then cyclized to give the corresponding N-alkoxy-carbonylalkyl derivative which is converted into the corresponding amide by treatment with ammonia or with a mono- or di-substituted amine. The compounds produced by the present invention improve learning memory and display a protecting effect against the E.E.G. consequence of an overdose of barbituates and against the reduced performance following brain damage (e.g. cerebral edema).

REFERENCES:
Aatnaa, E. et al., "J. Int. Med. Res.," (1975) 3, pp. 352-356.

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