4-Hydroxy-benzhydrols, process for their preparation and pharmac

Details 4-Hydroxy-benzhydrols, process for their preparation and pharmac 4-Hydroxy-benzhydrols, process for their preparation and pharmac

1983-12-27

1985-04-02

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568744, 568745, 568765, 568775, 568809, 568811, 568812, C07C 3911

Patent

active

045089264

ABSTRACT:
The invention relates to new 4-hydroxy-benzhydrols of the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms, with the proviso that if R.sub.1 is hydrogen, R.sub.2 is other than hydrogen or a 3-trifluoromethyl group, or if R.sub.1 is a 2-methyl group, R.sub.2 is other than a 5-methyl group.
According to another aspect of the invention there are provided processes for the preparation of these compounds.
The compounds of the formula (I) are pharmacologically active. In particular, they are suitable for the treatment of acute ethanolic intoxication. Pharmaceutical compositions containing them as active ingredients are also within the scope of the invention.

REFERENCES:
patent: 2247404 (1941-07-01), Perkins et al.
patent: 2719866 (1955-10-01), Gerzon
patent: 3943122 (1976-03-01), Sailor
patent: 4094908 (1978-06-01), Toth et al.

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