4-Hydroxy-.alpha.-[(3,4-methylenedioxyphenyl)isopropylaminoethyl

Details 4-Hydroxy-.alpha.-[(3,4-methylenedioxyphenyl)isopropylaminoethyl 4-Hydroxy-.alpha.-[(3,4-methylenedioxyphenyl)isopropylaminoethyl

1975-03-25

1976-06-29

Love, Ethel G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424282, C07D31744

Patent

active

039667707

ABSTRACT:
4-Hydroxy-.alpha.-[(3,4-methylenedioxyphenyl)isopropylaminomethyl]-3-(methy lsulfonylmethyl)benzyl alcohol having .beta.-adrenergic stimulant activity, particularly as a selective bronchodilator, is prepared from 4-hydroxyacetophenone by conversion to 3-methylsulfonylmethylacetophenone, bromination and conversion of this phenone to the phenylglyoxal and treatment of the resulting glyoxal derivative with 3,4-methylenedioxyphenylisopropylamine followed by simultaneous reduction of the imine and ketone moieties and catalytic hydrogenation to remove the benzyl group.

REFERENCES:
patent: 3341584 (1967-09-01), Larsen et al.
patent: 3711545 (1973-01-01), Kaiser et al.
Collin et al., Journ. Med. Chem., vol. 13, No. 4, 1970, pp. 674-680.

Affiliated with

Also associated with

Rating

4-Hydroxy-.alpha.-[(3,4-methylenedioxyphenyl)isopropylaminoethyl does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4-Hydroxy-.alpha.-[(3,4-methylenedioxyphenyl)isopropylaminoethyl, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-Hydroxy-.alpha.-[(3,4-methylenedioxyphenyl)isopropylaminoethyl will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1277529