4-Hydroxy-5-substituted-3(2H)-isothiazolone-1,1-dioxide derivati

Details 4-Hydroxy-5-substituted-3(2H)-isothiazolone-1,1-dioxide derivati 4-Hydroxy-5-substituted-3(2H)-isothiazolone-1,1-dioxide derivati

1980-12-29

1984-02-14

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548205, 548206, 548213, 548214, A61K 3144, C07D27502

Patent

active

044316526

ABSTRACT:
4-Hydroxy-5-substituted-3(2H)-isothiazolone-1,1-dioxide derivatives of the formula: ##STR1## where X and Y are independently selected from the group consisting of hydrogen, halogen, and C.sub.1-6 alkyl; provided that positions 2 and 6 of the substituted phenyl moiety may not be substituted by C.sub.3-6 alkyl; or a pharmaceutically acceptable salt thereof;
useful in treating urinary tract, especially renal calcium oxalate lithiasis.

REFERENCES:
patent: 3849430 (1974-11-01), Lewis
patent: 4067878 (1978-01-01), Miller
patent: 4346094 (1982-08-01), Beck et al.
Cottet et al., "Is There Treatment for Calcium Nephrolithiasis?", Nouv. Presse Med. 5(3): 139-145 (1976).
Hautmann et al., "Calcium Oxylate . . . Disease . . . ", J. of Urology, pp. 712-715 (1978).
Randall et al., "Quantitative Structure . . . ," J. Med. Chem. 22:608 (1979).
Schwam et al., "Purification . . . Liver Glycolate . . . ", Biochemistry 13:2828-(1979).
Melon et al., "Experimental Oxalic Lithiasis . . . ," Therapie XXVI 991-998 (1971).
Thomas et al., "Traitement Hypooxalurigue . . . ," Therapie XXVI 999-1005 (1971).
Melon and Thomas, "Oxylate Nephrolithiasis . . . ", Agressologie 14(6): 357-365 (1973).
Thomas et al., "Succinate," J. d'Urologie et Nephrologie 80, No. 9 (1974).
Richardson, K. E., "Effect of Partial Hepatectomy . . . ", Toxicology and Pharmacology 24: 530-538 (1973).
J. Thomas, et al., "Recent Data on the Urinary Excretion . . . ", Ann. Urol. 6:(1): W 31-33 (1972).
Watts et al., ". . . Treatment . . . Hyperoxylurea . . . ," Quarterly J. of Med., (New Series) No. 190, pp. 259-272 (1978).
Scott et al, "Reduction in Urinary Oxylate . . . ", Urology, vol. 12: 212-214 (1978).
Smith, Lloyd, "Symposium on Stones," Amer. J. Medicine, pp. 649-653 (1968).
Williams, Hibbard et al., "Disorders of Oxylate Metabolism", Amer. J. Medicine, pp. 715-731 (1968).
Liao and Richardson, "Inhabition Oxalate Biosynthesis . . . ", Archives Biochem. and Biophysics 154: 68-75 (1972).
Liao and Richardson, "Metabolism Oxylate Precursers . . . ", Archives Biochemistry and Biophysics 153: 438-448 (1972).
Melon and Thomas, "Experimental Oxylate Lithiasis", Therapie 26: 985-990 (1971).
Lewis et al., J. Het. Chem., p. 591 (1971).
Burger, Medicinal Chemistry, p. 42.
Randall et al., J. Med. Chem., 22, p. 608.

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