Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-08-27
2010-11-16
Habte, Kahsay T (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S012000, C544S013000
Reexamination Certificate
active
07834009
ABSTRACT:
The invention is directed to 4-hydroxy-5,6-dihydro-1H-pyridin-2-one compounds of Formula I and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus:wherein R6isX is N,Ring A is a 5- or 6-membered aryl, optionally substituted by 1-3 R8moieties,n is 2, andR1-R6and R8are defined herein.
REFERENCES:
patent: 7582626 (2009-09-01), Tran et al.
patent: 2005/0153877 (2005-07-01), Miao et al.
patent: 2006/0040927 (2006-02-01), Blake et al.
patent: 2006/0189602 (2006-08-01), Zhou et al.
patent: 2006/0211695 (2006-09-01), Borzilleri et al.
patent: 2006/0252785 (2006-11-01), Blake et al.
patent: WO-01/85172 (2001-11-01), None
patent: WO-02/098424 (2002-12-01), None
patent: WO-03/059356 (2003-07-01), None
patent: WO-2006115221 (2006-11-01), None
Vippagunta et al. “Crystalline Solids,” Advanced Drug Delivery Reviews, 2001, 48, pp. 3-26).
U.S. Appl. No. 11/766,668, Ellis et al.
U.S. Appl. No. 11/898,334, Zhou et al.
U.S. Appl. No. 11/861,678, Dragovich et al.
U.S. Appl. No. 11/955,144, Tran et al.
U.S. Appl. No. 11/955,193, Ruebsam et al.
U.S. Appl. No. 12/048,933, Ruebsam et al.
U.S. Appl. No. 12/061,499, Tran et al.
U.S. Appl. No. 11/845,515, Ellis et al.
Int'l Search Report of In'tl Appl. No. PCT/US05/45588.
Tedesco et al., 3-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, Potent Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase, J. Med. Chem. 49:971-983 (2006).
Fisyuk et al., Synthesis of 5,6-Dihydropyridin-2(1H)-ones, 1,5,6,8,8a-Hexahydroisoquinolin-3(2H)-ones and 4a,5,6,7,8,8a-Hexahydroquinolin-2(1 H)-ones by Intramolecular Wittig Reaction. Molecules, Feb. 28, 2002, vol. 7, pp. 124-128.
Ellis David
Li Liansheng
Ruebsam Frank
Tran Chinh V.
Zhou Yuefen
Anadys Pharmaceuticals, Inc.
Connolly Bove & Lodge & Hutz LLP
Habte Kahsay T
LandOfFree
4-hydroxy-5,6-dihydro-1 H -pyridin-2-one compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 4-hydroxy-5,6-dihydro-1 H -pyridin-2-one compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-hydroxy-5,6-dihydro-1 H -pyridin-2-one compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4164067