4-hydroxy-4-(substituted alkenyl)cyclohexanecarboxylic acids

Details 4-hydroxy-4-(substituted alkenyl)cyclohexanecarboxylic acids 4-hydroxy-4-(substituted alkenyl)cyclohexanecarboxylic acids

1986-11-07

1988-05-31

Moyer, Donald B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

514826, 560 16, 560 18, 560125, 562432, 564154, C07C14926, C07C149273, A61K 31215, A61K 3119

Patent

active

047482745

ABSTRACT:
The present invention relates to compounds which are 4-hydroxy-4-alkenylcyclohexanecarboxylic acid derivatives possessing leukotriene antagonist activity. The compounds are useful in the treatment of allergic diseases, particularly in the treatment of human asthma. They are prepared by the reaction of an appropriate oxaspiro compound with a mercaptoalkanoic acid derivative.

REFERENCES:
patent: 4622422 (1986-11-01), Cregge et al.
Noller, Chemistry of Organic Compounds, 2nd ed., W. B. Saunders Co., 1957, pp. 740-741.
Streitwieser et al., Introduction to Organic Chemistry, Macmillan Publishing Co., Inc., New York, 1976, pp. 242-243.

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