4-Hydroxy-4-dedimethylamino-tetracyclines

Details 4-Hydroxy-4-dedimethylamino-tetracyclines 4-Hydroxy-4-dedimethylamino-tetracyclines

1973-01-22

1978-01-03

Coughlan, Jr., Paul M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260268PT, C07C10319

Patent

active

040666948

ABSTRACT:
4-Dedimethylaminotetracyclines and the corresponding 5a,6-anhydro derivatives having an oxo, hydroxy, substituted imino, amino or substituted amino group other than dimethylamino at the C.multidot.4-position useful as antimicrobial agents. The 4-oxo-4-dedimethylaminotetracyclines are prepared by oxidation of tetracyclines with a hydrocarbon dicarboxylic acid haloimide and then converted by reduction to the corresponding 4-hydroxy compounds or by reaction with a primary amine to 4-substituted imino derivatives. The latter compounds are reduced to 4-amino derivatives which are reductively methylated or alkylated to 4-substituted-4-dedimethylaminotetracyclines. Dehydration of the tetracycline compounds affords the corresponding 5a,6-anhydro compounds.

REFERENCES:
patent: 2744931 (1956-05-01), Broschard et al.
patent: 3030377 (1962-04-01), Soder et al.
patent: 3364260 (1968-01-01), Neidleman
patent: 3462487 (1969-08-01), Kinney et al.
patent: 3609188 (1971-09-01), Esse et al.

Affiliated with

Also associated with

Rating

4-Hydroxy-4-dedimethylamino-tetracyclines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4-Hydroxy-4-dedimethylamino-tetracyclines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-Hydroxy-4-dedimethylamino-tetracyclines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-280999