4-Hydroxy-3-nitro-pyrido[2,3-B]pyridine-2(1H)-ones

Details 4-Hydroxy-3-nitro-pyrido[2,3-B]pyridine-2(1H)-ones 4-Hydroxy-3-nitro-pyrido[2,3-B]pyridine-2(1H)-ones

1976-07-21

1981-04-28

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546123, A61K 31435, C07D48704

Patent

active

042646022

ABSTRACT:
Anti-allergic 4-hydroxy-3-nitro-pyrido[2,3-b]pyridines-2(1H)-ones are prepared by reacting a 3,4-dihydro-1,3-dioxo-1H-pyrido[2,3-d][1,3]oxazine (a 3-azaisatoic anhydride) with the carbanion resulting from the reaction of nitro acetic acid alkyl esters with a proton abstracting agent.

REFERENCES:
patent: 3864493 (1975-02-01), Cairns et al.
patent: 3879544 (1975-04-01), Reisner et al.
patent: 3883653 (1975-05-01), Barth
patent: 3885038 (1975-05-01), Pfister et al.
Buckle, D. R., et al., "4-Hydroxy-3-nitro-2-quinolones and Related Compounds as Inhibitors of Allergic Reaction, J. Medicinal Chem. '75, vol. 18, #7, pp. 726-732.
Physicians Desk Reference (PDR), (1974), pp. 760-761.

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