4-hydroxy-2-cyclopentenone, process for production thereof, phar

Details 4-hydroxy-2-cyclopentenone, process for production thereof, phar 4-hydroxy-2-cyclopentenone, process for production thereof, phar

1985-10-22

1987-12-08

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514573, 514690, 514684, 568379, 568380, 568375, 568376, 568330, 558441, 560121, 560122, 560231, 560255, 562503, 562504, A61K 3119

Patent

active

047118954

ABSTRACT:
A 4-hydroxy-2-cyclopentenone represented by the following formula (I) ##STR1## wherein X represents a hydrogen or halogen atom, A represents a hydrogen atom and B represents a hydroxyl group, or A and B are bonded to each other to represent a bond, R.sup.1 represents a substituted or unsubstituted alkyl, alkenyl or alkynyl group having 1 to 10 carbon atoms, R.sup.2 represents a substituted or unsubstituted alkyl, alkenyl or alkynyl group having 1 to 10 carbon atoms, and R.sup.3 represents a hydrogen atom or a protective group for a hydroxyl group, provided that R.sup.2 is not a 2-octenyl, 8-acetoxy-2-octenyl or 2,5-octadienyl group. The compounds of formula (I) in which A is hydrogen and B is hydroxyl group are prepared by subjecting a 5-unsubstituted cyclopentenone and an aldehyde to aldol condensation reaction. The compounds of formula (I) in which A and B form a bond is prepared by subjecting the compounds of the formula (I) in which A is hydrogen and B is hydroxyl group to dehydration. The compounds (I) are useful for treatment of malignant tumors.

REFERENCES:
patent: 4560703 (1985-12-01), Fukushima et al.
Monthly Drugs & Medical Inst., vol. 24, pp. 37-4/1982).

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