4-Heterocyclic peperidines promote release of growth hormone

Details 4-Heterocyclic peperidines promote release of growth hormone 4-Heterocyclic peperidines promote release of growth hormone

1994-10-26

1998-06-16

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142268, 5142278, 5142305, 5142322, 514259, 514264, 514312, 514314, 514315, 514319, 514320, 514321, 514322, 514323, 514324, 514326, 514338, 514339, 514341, 514342, 514343, 544 55, 544 60, 544 90, 544 96, 544111, 544124, 544129, 544235, 544238, 544253, 544284, 544353, 544360, 546188, 546192, 546193, 546197, 546198, 546199, 546200, 546201, 5462701, 5462704, 5462711, 5462714, 5462724, 5462734, 5462737, 5462741, 5462744, 5462757, 5462761, 5462834, 5462841, 546202, 546209, 546210, 546212, 546213, 546268, 546269,

Patent

active

057671184

ABSTRACT:
The present invention is directed to certain novel compounds identified as 4-heterocycle substituted piperidines of the general structural formula: ##STR1## wherein R.sup.1, R.sup.4, R.sup.5, A, R.sup.3 and the dashed line are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.

REFERENCES:
patent: 5206235 (1993-04-01), Fisher et al.
patent: 5273989 (1993-12-01), Schwartz et al.
patent: 5492916 (1996-02-01), Morriello
patent: 5492920 (1996-02-01), Chen
patent: 5494919 (1996-02-01), Morriello

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