4-Heteroarylimidazo-[1,5-A]pyrimidines

Details 4-Heteroarylimidazo-[1,5-A]pyrimidines 4-Heteroarylimidazo-[1,5-A]pyrimidines

1981-11-05

1983-02-22

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

424251, 542421, 546278, 548336, C07D52100, A61K 31505

Patent

active

043749887

ABSTRACT:
Novel pyrimidine compounds are disclosed of the class represented by the formula: ##STR1## wherein R.sub.1 is selected from the class consisting essentially of hydrogen, chloro, bromo, cyano (--CN), carbamoyl (--CO--NH.sub.2), carboxyl (--COOH), and lower alkoxycarbonyl (--CO--O--R.sub.3, where R.sub.3 is a lower alkyl radical having 1-4 carbon atoms), and wherein R.sub.2 is a monovalent radical selected from the class consisting essentially of furyl, thienyl, 3-pyridyl and 3-pyridyl-N-oxide, either of said pyridyl radicals optionally being substituted with an alkyl radical having from 1 to 4 carbon atoms. Processes of preparing such compounds are disclosed.
The novel compounds are useful as anxiolytic agents in ameliorating anxiety in a mammal.

REFERENCES:
patent: 3105834 (1963-10-01), Wei
patent: 4153695 (1979-05-01), Turner
patent: 4178449 (1979-12-01), Dusza et al.
patent: 4236005 (1980-11-01), Dusza et al.
Novinson, et al., "Journal of Heterocyclic Chemistry," vol. 11, No. 6, 1974, pp. 873-878.

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