4-heteroaryl-1,3-benzodiazepines and 2-substituted-.alpha.-(hete

Details 4-heteroaryl-1,3-benzodiazepines and 2-substituted-.alpha.-(hete 4-heteroaryl-1,3-benzodiazepines and 2-substituted-.alpha.-(hete

1992-04-22

1994-03-08

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514438, 546329, 546334, 546337, 548202, 548204, 548205, 5483355, 5483751, 548561, 549 74, 549 75, 549 77, 549492, 549493, 540567, C07D 3320, C07D21338, A61K 3144, A61K 3138

Patent

active

052927601

ABSTRACT:
Novel 4,5-dihydro-4-heteroaryl-3H-1,3-benzodiazepines, intermediates, processes for the preparation thereof, and methods for treating depression, inhibiting convulsions and treating anxiety utilizing compounds and compositions thereof are disclosed.

REFERENCES:
P. K. Kadaba, Drugs of the Future, 15, pp. 1013-1024, 1990.
J. B. Uney et al., Scrip Reports Neurodegeneration and Neuroprotection, "Molecular and Cellular Events Accompanying Nerve Cell Death", pp. 35-40, 1990.
SCRIP Reports, Neurodegeneration and Neuroprotection, M. V. Sonfroniew et al., "Experimental Models of Neuronal Degeneration and Alzheimer's Disease", pp. 10-16 (1990).
D. M. Barnes on Science, 235, 632 (1987).

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