4-halogeno-2-oxyimino-3-oxobutyric acids and derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Silicon containing

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556415, 560147, 560168, 548110, C07F 710

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active

048452572

ABSTRACT:
A method of producing a 4-halo-2-(substituted or unsubstituted)hydroxyimino-3-oxobutyric acid ester or amide, which is a synthetic intermediate of value for the production of cephalosporins containing an aminothiazole group, characterized by reacting a 2-(substituted or unsubstituted)-hydroxyimino-3-oxobutyric acid or an ester or amide thereof with a silylating agent and reacting the resulting novel 2-(substituted)hydroxyimino-3-silyloxy-3-butenoic acid ester or amide with a halogenating agent.

REFERENCES:
patent: 3560543 (1971-04-01), Plueddemann
patent: 3833633 (1974-09-01), Owen et al.
patent: 3856848 (1974-12-01), Smithwick
patent: 4554369 (1985-11-01), Hill et al.
patent: 4709067 (1987-11-01), Shibasaki et al.
Chem. Pharm. Bull. 25, pp. 3115-3117 (1977).
Journal Antibiotics, 38, pp. 1738-1751 (1985).
Journal of the chemical Society of Japan 1981, No. 5, pp. 785-803 (English Translation of Relative Portions in the Items "2.9.1" and "3.3.2" at pp. 792 and 798).

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