4-Halo etianic acids and derivatives thereof

Details 4-Halo etianic acids and derivatives thereof 4-Halo etianic acids and derivatives thereof

1979-11-19

1981-04-14

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2603971, 26039745, 26023955D, 2602395, C07J 7100, A61K 3156

Patent

active

042619866

ABSTRACT:
Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17.beta.-carboxylic acids and esters substituted at the 4-position with a fluoro or chloro and optionally substituted at the six position with fluoro or chloro are useful as anti-inflammatory steroids. These compounds are optionally substituted at the 9.alpha.-position with fluoro, chloro or bromo; substituted at the 11 with a keto, a .beta.-hydroxy or a .beta.-chloro (the latter only when there is a 9.alpha.-chloro); substituted at 16.alpha. (or 16.beta.) with methyl or hydrogen, and at 17.alpha. with hydroxy or an ester.

REFERENCES:
patent: 3232960 (1966-02-01), Magerlein et al.
patent: 3707537 (1972-12-01), Kierstead et al.
patent: 4093721 (1978-06-01), Phillipps et al.

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