4'-Fluoro-4-{[4-(phenyl)cyclohexyl]amino}butyrophenones and the

Details 4'-Fluoro-4-{[4-(phenyl)cyclohexyl]amino}butyrophenones and the 4'-Fluoro-4-{[4-(phenyl)cyclohexyl]amino}butyrophenones and the

1973-02-02

1976-06-01

Hines, Robert V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260141, 260239B, 2602477Z, 260268R, 26029372, 26029383, 2602955S, 2603265R, 2603407, 260349, 260456R, 260456P, 260471C, 2605011, 26050112, 26050118, 260556A, 26050119, 260556AR, 260562A, 260566A, 260556AC, 2605676M, 260570R, 2605705C, 260590D, 260611A, 260 68R, 424244, 424250, 424274, 424316, 424266, 424330, 424267, C07C 9710

Patent

active

039609618

ABSTRACT:
This invention relates to novel 4-phenylcyclohexylamines embraced by the formula ##SPC1##
Wherein .about. is a generic expression denoting cis and trans stereoconfiguration and mixtures thereof; R is selected from the group consisting of alkyl of from one through four carbon atoms, fluorine, chlorine, bromine, trifluoromethyl, nitro and alkoxy of from one through four carbon atoms; R' and R.sup.1 are selected from the group consisting of hydrogen and alkyl of from one through four carbon atoms; R.sup.2 is selected from the group consisting of hydrogen, alkyl of from one through four carbon atoms, alkanoyl of from one through three carbon atoms, alkylsulfonyl of from one through three carbon atoms, arylsulfonyl of from six through ten carbon atoms, alkylcarbamoyl wherein alkyl is from one through four carbon atoms, alkoxycarbonyl wherein alkyl is from one through four carbon atoms, ring monosubstituted aroylalkyl wherein the substituents have the same meaning as R, above, aryl is from six through ten carbon atoms and alkyl is from one through six carbon atoms and bis (ring monosubstituted) arylalkyl wherein the substituents have the same meaning as R, above, aryl is from six through ten carbon atoms and alkyl is from one through six carbon atoms; R.sup.1 and R.sup.2 when taken together with --N< is a saturated heterocyclic amino radical selected from the group consisting of unsubstituted and monosubstituted pyrrolidino, piperidino, hexamethylenimino, morpholino and piperazino; and an acid addition salt thereof. It also relates to intermediates and processes for the preparation of the aforesaid novel compounds (1) and novel derivatives thereof. The systemic administration to humans and animals of the novel compounds (1) depresses their central nervous systems.

REFERENCES:
Lednicer et al., "Journal Medicinal Chem.", vol. 15, No. 12, pp. 1240-1243 (1972).

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