4-ethoxy-5-fluoro-2'-deoxyuridine

Details 4-ethoxy-5-fluoro-2'-deoxyuridine 4-ethoxy-5-fluoro-2'-deoxyuridine

1994-08-11

1996-06-25

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2854, C07H 19073, A61K 3170

Patent

active

055301100

ABSTRACT:
4-Ethoxy-5-fluoro-2'-deoxyuridine is disclosed as an intermediate in the synthesis of 5'-fluoro-2'-deoxycytidine. The treatment of 4-ethoxy-5-fluoro-2'-deoxyuridine with methanolic ammonia eliminates the side product of 5-fluoro-2'-deoxyuridine which occurs when 4-methoxy-5-fluoro-2'-deoxyuridine is used as the reactant. 4-Ethoxy-5-fluoro-2'-deoxyuridine is also a prodrug of 5-fluoro-2'-deoxyuridine which is substantially less toxic than parent free nucleoside 5-fluoro-2'-deoxyuridine.

REFERENCES:
patent: 3404144 (1968-10-01), Fox et al.
patent: 4754026 (1988-06-01), Kawada et al.
Divakar et al. J. Chem. Soc. Perkin Trans. I pp. 1171-1176, 1982.
Chemical Abstracts, vol. 97, No. 7, Abstr. No. 56191h, p. 690, 1982, Funai Pharmaceutical Industries, Ltd. JPN Kokai Tokyo Koho JP 82 28,083.
Sowers, et al., J. Biol. Chem. 263(29): 14794-14801 (1988).
Martin et al. J. Pharm. Sci. 76(2): 180-184, 1987.

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