4-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-napthalen...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

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C564S139000

Reexamination Certificate

active

07968602

ABSTRACT:
Analogs of 4-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-napthalenyl)-1-propenyl]benzoic acid and methods of manufacture and use thereof, such as for use in cancer prevention and treatment.

REFERENCES:
patent: 4326055 (1982-04-01), Loeliger
patent: 5516792 (1996-05-01), Curley, Jr. et al.
patent: 5574177 (1996-11-01), Curley, Jr. et al.
patent: 5599953 (1997-02-01), Curley, Jr. et al.
patent: 5663377 (1997-09-01), Curley, Jr. et al.
patent: 6117845 (2000-09-01), Curley, Jr. et al.
patent: 7585894 (2009-09-01), Curley, Jr. et al.
Lotan et al. J. Nutr. Growth Cancer (1983) vol. 1, No. 2, pp. 71-76.
Submitted to Applicant in the parent, U.S. Appl. No. 11/428,165.
Abou-Issa et al., (1988) Putative metabolites derived from dietary combinations of calcium glucarate andN-(4-hydroxyphenyl)retinamide act synergistically to inhibit the induction of rat mammary tumors by 7,12-dimethylbenz[α]anthracene,Proc. Natl Acad Sci USA, 85:4181-4184.
Boehm et al., (1994) Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids,J Med Chem, 37:2930-2941.
Bollenbeck et al., (1955) The Synthesis of Aryl-D-glucopyranosiduronic Acids,J Am Chem Soc, 77:3310.
Bradford MM, (1976) A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding,Anal Biochem, 72:248-254.
Bruson et al., (1940) Cycli-Alkylation of Aromatic Compounds by the Friedel and Crafts Reaction,J Am Chem Soc, 62:36.
Chapman et al., (2003) Hydrolysis of 4-HPR to atRA occurs in vivo but is not requires for retinamide-induced apoptosis,Arch Biochem Biophys, 419:234-243.
Cheng et al., (2005) Synthesis and Enzyme-Specific Activation of Carbohydrate-Geldanamycin Conjugates with Potent Anticancer Activity,J Med Chem, 48(2):645.
Costa et al., (1989) Tolerability of the Synthetic Retinoid Fenretinide® (HPR),Eur J Cancer Clin Oncol., vol. 25, No. 5, pp. 805-808.
Dawson et al., (1984) A Method for the Stereoselective Synthesis of (E)-Methylstilbene Retinoids,J. Org. Chem, 49:5265.
Hill et al., (1992) Retinoids and Cancer Prevention,Ann Rev Nutrition, 12:161-181.
Kaiser-Kupfer et al., (1989) Abnormal Retinal Function Associated with Fenretinide, A Synthetic Retinoid Fenretinide (HPR),Eur J Cancer Clin Oncol, 25:805-808.
Kenel et al., (1988) Teratogenicity of N-(4-hydroxyphenyl)-all-trans Retinamide in Rats and Rabbits,Teratogenesis, Carcinogenesis and Mutagenesis, 8:1-11.
Kochhar et al., (1992) Retinamides: Hydrolytic Conversion of Retinoylglycine to Retinoic Acid in Pregnant Mice Contributes to Teratogenicity,Teratology, 45:175-178.
Krust et al., (1989) A third human retinoic acid receptor, hRAR-γ,Proc. Natl. Acad. Sci. USA, col. 86, pp. 5310-5314.
Lotan et al., (1983)The proliferation of melanoma cells in culture,J. Nutri. Growth Cancer, vol. 1, No. 2, pp. 71-76.
Mehta et al., (1991) The Effects of Retinoid Glucuronides on Mammary Gland Development in Organ Culture,Oncology, 48:505-509.
Moon et al., (1979)N-(4-Hydroxyphenyl)retinamide, A New Retinoid for Prevention of Breast Cancer in the Rat,Cancer Res.39:1339-1346.
Munder et al., (1995) Identification of procine intestinal accessory factor that enables DNA sequences recognition by vitamin D receptor,Proc Natl Acad Sci USA, 92:2795-2799.
Newton et al., (1980) Structure-Activity Relationships of Retinoids in Hamster Tracheal Organ Culture,Cancer Res. 40:3413-3425.
Reppa et al., (1993) All-transretinol is a ligand for the retinoic acid receptors,Proc Natl Acad Sci USA, 90:7293-7297.
Reppa et al., (1996) All-trans3,4-didehydroretinoic acid equals all-transretinoic acid in support of chick neuronal development,FASEB J, 10:1078-1084.
Roberge et al., (1994) N-linked analogs of retinoid O-glucuronides: Potential cancer chemopreventive-chemotherapeutic agents,Bioorg Med Chem Lett, 4(17):2117-2122.
Simoni et al., (2001) Retinoic Acid and Analogs as Potent Inducers of Differentiation and Apoptosis: New Promising Chemopreventative and Chemotherapeutic Agents in Oncology,Pure Appl Chem, 73:1437-1444.
Solladie et al., (2003) A re-investigation of resveratrol synthesis by Perkins reaction. Application to the synthesis of aryl cinnamic acidsTetrahedron, 59:3315.
Wagner et al., (1992) Regional differences in retinoid release from embryonic neural tissue detected by an in vitro reporter assay,Development, 116:55-56.
Wood et al., (1963), Polycyclic Musks. I. Acyl- and Dinitropolyalkyltetralin Derivatives,J of Org Chem, 28(9):2248.

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