4-dihydroinden-2-yl-, 4-tetrahydronaphth-2-yl-, and 4-dihydroben

Details 4-dihydroinden-2-yl-, 4-tetrahydronaphth-2-yl-, and 4-dihydroben 4-dihydroinden-2-yl-, 4-tetrahydronaphth-2-yl-, and 4-dihydroben

1985-11-21

1987-08-25

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514397, 548336, 548346, A61K 31415, C07D23364, C07D40504

Patent

active

046893393

ABSTRACT:
A process for the preparation of a substituted imidazole of the formula ##STR1## wherein X is --CH.sub.2 --, --CH.sub.2 CH.sub.2 -- or --O-- R.sub.1 is H, lower alkyl or lower alkenyl, OCH.sub.3 or OCH.sub.2 CH.sub.3, R.sub.2 is H, CH.sub.3, CH.sub.2 CH.sub.3, OCH.sub.3 or OH, R.sub.3 is H, CH.sub.3, CH.sub.2 CH.sub.3, OCH.sub.3 or Hal, R.sub.4 is H, CH.sub.3, CH.sub.2 CH.sub.3, OCH.sub.3 or Hal, and Hal is halogen and their non-toxic acid addition salts exhibit valuable pharmacological activity and are useful especially as selective .alpha..sub.2 -receptor antagonists.

REFERENCES:
patent: 4302469 (1981-11-01), Kluge et al.
patent: 4342775 (1982-08-01), Cozzi et al.
Chemical Abstracts, vol. 101, 16791y, 1984.
.alpha.-Adrenoreceptor Reagents, 2, Effects of Modiciation of the 1,4-Benzodioxan Ring System on .alpha.-Adrenoreceptor Activity, Chapleo et al.; J. Med. Chem. 1984, vol. 27, pp. 570-576.

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