4-(diarylmethyl)-1-piperazinyl derivatives

Details 4-(diarylmethyl)-1-piperazinyl derivatives 4-(diarylmethyl)-1-piperazinyl derivatives

2007-11-20

2007-11-20

Tucker, Zachary C. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S358000, C544S398000

Reexamination Certificate

active

10509052

ABSTRACT:
A compound of formula Iwherein X, Y, X′ & Y′ are selected from hydrogen, halogen, substituted or unsubstituted alkyl (linear, branched or cyclo), aryl, alkyloxy and haloalkyl group; R1, R2, R3& R4are selected from hydrogen, substituted or unsubstituted alkyl groups (linear, branched or cyclo), aryl, heteroaryl groups or aralkyl groups, heterocycles containing one or more of hetero atoms (viz., N, S, O), substituted or unsubstituted alkenyl or alkynyl groups of carbon 2 to 6; wherein the substituents R1& R2on the piperazinyl moiety are either syn or anti to each other and optionally R3and R4together with the carbons to which they are attached form a monocyclic saturated or aryl or substituted aryl or heteroaryl or substituted heteroaryl ring containing one or more hetero atoms selected from N, S and O with a ring size ranging from 3 to 6; with a proviso that when R3& R4together do not form part of a ring they may exist in either E or Z configuration; R5is (CH2)n—O—CH2—CO-Z wherein n is 1 to 6; Z is selected from OH, OR, NRR′, N(OR)R′, N(R)—N(R)R′andwherein R & R′ are selected from hydrogen, substituted or unsubstituted alkyl groups (linear, branched or cyclo), aryl, heteroaryl groups or aralkyl groups, heterocycles containing one or more of hetero atoms (viz., N, S, O), substituted or unsubstituted alkenyl or alkynyl groups of carbon 2 to 6; and B is selected from —(CH2)n-(n is 1 to 6) and —(CH2)x-D-(CH2)y where D is O, NR, S or SO2, x and y are independently 1 to 6; and m is selected from 1 to 6; and pharmaceutically acceptable salts thereof.

REFERENCES:
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patent: 01/29016 (2001-04-01), None
patent: 01/79188 (2001-10-01), None

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